Your Good Health: Medications not a cure for being overweight

Dear Dr. Roach: I am looking for advice on diet pills. I have tried everything. I eat well, go to the gym and walk, but my meniscus problem limits my walking speed. Since menopause, I have gained 30 pounds. I am sure there is something out there that will kick-start my metabolism. I am so depressed and my doctor has no sympathy.


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Difficulty losing excess weight is one of the greatest public-health problems in industrial countries, and I’m not going to solve it here, but I’ll try to discuss principles of drug treatment for weight.

One critical issue is to look at any medications you are taking. Many can cause weight gain, and some, such as beta blockers, often used for high blood pressure, are unrecognized by many doctors. Stopping medicines that predispose to weight gain is critical.

Depression is a predisposing factor to weight gain. Some people lose weight with depression, but my experience is that weight gain is much more common. Many anti-depression medicines cause weight gain. One, bupropion, commonly causes weight loss.

Among medicines specifically for weight loss, most work either by decreasing fat absorption or by reducing appetite. They don’t really increase metabolism, with the exception of phentermine, which does increase resting energy expenditure somewhat and may be useful in preventing weight regain in people who have lost weight, for whom metabolism does often slow down.

Orlistat (called Xenical by prescription, Alli over-the-counter) prevents the body from absorbing some of the fat in the diet. The fat is then excreted through stool. This may cause many people to have gastrointestinal side-effects, which are diminished when on a low-fat diet. Orlistat caused people to lose about seven pounds more than placebo.

There are several drugs that work on appetite. Liraglutide is a diabetes medicine that has been found to be helpful in overweight people even without diabetes. Metformin is another diabetes medicine that is sometimes used for weight loss, although it does not have a U.S. Food and Drug Administration indication for this. Both of these diabetes drugs often have gastrointestinal side-effects. Lorcaserin (Belviq) is about as effective as orlistat, but with fewer side effects (headache was the most common).

Some weight-loss experts use combination drugs, including phentermine/topiramate (Qsymia) and bupropion/naltrexone (Contrave). These have more significant risks. I don’t prescribe these drugs, but I do refer my patients who are interested in medication treatment to a weight-loss expert.

It’s important to remember that medications are not a cure for being overweight. Once the medicines stop, weight is expected to rise, unless a person makes significant changes in diet and exercise.

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